Physics: Life is the duration or process of evolution of things. Biology: Internal condition that categorizes both its similarities and differences to living beings. Biochemistry: State achieved by molecular structures, with the capacity to develop, maintain an environment and reproduce. Religions: life has spiritual and transcendental connotations.
The fate of the universe is determined by the density of the universe. Some Theories about the end of the universe: Thermal death of the universe because it is too cold to have life. Big Rip all forms of life, no matter how small they are, they will disintegrate into unbound elementary particles. Big Crunch the universe would collapse into an a-dimensional spatio-temporal singularity.