Progressive Supranuclear Palsy

Author: Dr. Ricardo Kotliroff

Progressive Supranuclear Palsy

Definition

Progressive supranuclear palsy (PSP), also called Steele-Richardson-Olszewski Syndrome, is an uncommon neurodegenerative disease that affects brain cells.

Progressive Supranuclear Palsy Causes & Risk Factors

An estimated 3 to 6 of every 100,000 individuals throughout the world are afflicted with PSP, and middle-aged and elderly people are at higher risk of developing it. Sixty is the most common age that PSP presents, although some patients may experience initial symptoms starting as young as 40. Typically, men tend to be affected by PSP than women.

PSP is caused by cellular deterioration above nerve cell clusters, (neurons and glial cells, termed nuclei) in the midbrain and the brainstem, which is responsible for controlling body movement, and the frontal lobe, which controls thinking. Damage that occurs above the clusters of nerve cells is called supranuclear, and because the disease results in weakness of certain parts of the body, it is termed palsy.

Patients with PSP have been observed to have abnormal amounts of the tau protein inside deteriorating brain cells. These clumps of tau proteins interfere with the microtubule structures’ ability to send information (via axons of the nerve cells to other nerve cells in the brain), as well as cause cell death. One theory suggests that abnormal clumps of tau proteins may stimulate connected cells to produce clumps of tau protein. Tau clumps have also been found in other neurodegenerative diseases, including Alzheimer’s Disease.

Rare (under 1% of) cases of PSP occurring within certain families have been observed. Also, rare mutations in the MAPT gene, which is responsible for synthesizing tau protein, have been found in some patients with PSP.

Progressive Supranuclear Palsy Symptoms

As the name Progressive Supranuclear Palsy indicates, symptoms of the disease may worsen with time. Physical symptoms of PSP may include:

  • Troubles with the eyes including: abnormal eye movement, such as blinking, prolonged tearing, difficulty opening the eyes, burning sensations, and sensitivity to light
  • Abnormal speech involving: incorrect sounds (apraxia), which may occur early in disease, and slurred speech
  • Difficulty swallowing
  • Rigidity of facial muscles, causing a frightened or surprised look on the face
  • Sleep disturbances
  • Problems with balance
  • Tremors in the legs, feet, or hands
  • Difficulty walking

Emotional, behavioral, and cognitive symptoms of PSP may include:

  • Personality changes, such as more irritability
  • Reduced interest in pleasurable activities
  • Impulsive behavior, including crying or laughing in the absence of apparent reasons
  • Depression and/or anxiety
  • Cognitive difficulties in memory, reasoning, problem solving, and decision making.
    Progressive dementia is usually mild.

Complications

Patients with Progressive Supranuclear Palsy may become severely disabled withing 3 to 5 years after the onset of symptoms. The most common cause of death is Pneumonia. With good attention to medical and nutritional needs, it is possible for individuals with PSP to live at least a decade after the first symptoms of the disease start to appear.

Although the condition of PSP itself is not fatal, some of its complications are dangerous and may even be life-threatening.

Complications from PSP symptoms may include:

  • Abnormal movement of the eyes and an inability to aim the eyes correctly may affect vision. Some patients have problems looking down, or have blurred or double vision. Problems with visual focus may result in spilling of food. Additionally, due to the appearance of poor eye contact with others, PSP patients may seem uninterested during conversations. More seriously, vision problems can cause injuries.
  • Difficulty swallowing may result in a risk of choking or aspirating (i.e., inhaling) food or liquids into the airway. Pneumonia may develop from aspiration of food or liquid. Importantly, Pneumonia is the most common cause of death in patients with PSP. To avoid choking, physicians may suggest surgical implantation of a feeding tube.
  • Some patients may experience stiffness and awkward movements. Serious, permanent problems with balance may interfere with the ability to walk, increasing the risk of falling. Early in the disease, some patients experience a tendency to fall backwards. Falling can cause injuries to the head or fractures in other parts of the body.
  • Impulsive behaviors, including not waiting for help in mobility, can result in falling.

Diagnosis

Proper diagnosis by a neurologist or movement disorder specialist is important because physicians may sometimes confuse the symptoms of Progressive Supranuclear Palsy with those of Parkinson’s Disease, Alzheimer’s disease, or other forms of dementia.

Diagnosis may include taking a medical history, physical examination, neurological examination, and radiological tests such as magnetic resonance imaging (MRI) or positron emission tomography (PET) to find out whether shrinking in the upper part of the brainstem, a sign of PSP, has occurred; to identify other abnormalities in the brain; to measure brain activity in areas where degeneration is known to have occurred; and to exclude other conditions, such as stroke.

Types of Progressive Supranuclear Palsy

Patients with Progressive Supranuclear Palsy may be classified into two groups. PSP-Parkinsonism and PSP-Richardson. People with PSP-Parkinsonism may respond temporarily to the medication, Levodopa, before their illness progresses to characteristics of the PSP-Richardson group, the classical type of PSP.

Progressive Supranuclear Palsy Treatment

Conventional treatment may include certain medications, glasses with bifocal or prism lenses to improve issues with looking down, evaluations for speech and swallowing, walking aids (such as canes, walkers, or wheelchairs), physical and occupational therapy, and feeding tubes (gastrostomy, surgical implantation of a tube through the abdominal skin leading into the intestine) for patients with difficulty swallowing and/or risk of choking.

Currently, there is no known “cure” for Progressive Supranuclear Palsy. Thus, conventional treatment is limited to the management of signs and symptoms, and enhancing the comfort of the patient. However, conventional treatment by physicians allows survival of patients with Progressive Supranuclear Palsy to be at least 10 years following the presentation of initial symptoms.

Conventional medications include:

  • Eyedrops to keep eyes moist.
  • Injections of low doses of Botulisum toxin type A (Botox) into the muscles surrounding the eyes to block chemical signals causing contraction of muscles, thereby reducing spasms of the eyelids.
  • Medicines for Parkinson’s Disease to increase concentrations of dopamine, a chemical in the brain that involved in controlled movements of smooth muscles. For example, Levodopa may reduce tremors. However, the effects of these medicines last only 2 to 3 years.
  • Antidepressant medicines may relieve pain, reduce drooling, and improve mood.
  • Medicines to aid sleep.

Alternative therapy for PSP includes homeopathy, which seeks to treat the patient, rather than just the disease. Homeopathy is an effective method of healing acute and chronic conditions, as claimed by millions of patients worldwide and thousands of homeopathic doctors.

Our proprietary therapeutic methods are based on a belief that all humans possess certain foundational energy sources within their core, and that a person’s energy balance is tied directly to his/her state of health and wellbeing. When these energy sources are disturbed, whether from internal or external forces, disease occurs.

Our homeopathic treatments seek to neutralize these disturbances and restore a person’s natural, optimal energy balance.

Premilife wants to be your partner in managing Progressive Supranuclear Palsy!

Since our founding in 1980, Premilife has dedicated decades to helping patients throughout the world experience gradual improvement of progressive supranuclear palsy via homeopathy. View our success stories. Our homeopathic treatments are manufactured under strict quality guidelines for healthcare from the world’s health organizations.

Here is one of Premilife’s Progressive Supranuclear Palsy patient’s success stories:

Premilife’s unique homeopathic treatment, Antiverisan, is specifically designed and formulated to assist you in managing Progressive Supranuclear Palsy. The different ingredients in each pill increase your likelihood of success. You can take Antiverisan with any conventional PSP medicine that you might currently be using.

Get your treatment for Progressive Supranuclear Palsy now!

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45 thoughts on “Progressive Supranuclear Palsy

  1. mair cohen says:

    My brother who is 63 years old;has PSP and would like to know if you have a medication for it.
    We are living in Venezuela and looking forward to see how you can help him.
    Regards
    Mair Cohen

      • Premilife Customer Care says:

        Dear Mair Cohen
        Thank you for approaching us.
        We have answered your question in a personal mail sent to you. We hope you found our answer sufficient and that it provided you with the information you were looking for.
        If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
        The Premilife customer service

      • Ruben Costanzo says:

        Mi esposa Alicia, de 54 años, le diagnosticaron PSP hace 3 años, somos de Venezuela pero actualmente vivimos en México, Pueden ayudarnos con su tratamiento?
        Cordial saludo
        Rubén Costanzo

          • Premilife Customer Care says:

            Dear Hemangi
            Thank you for approaching us.
            We have answered your question in a personal mail sent to you.
            We hope you found our answer sufficient and that it provided you with the information you were looking for.
            If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
            The Premilife customer service

          • Rajeswari Dhurjati says:

            Hi,

            My mother (64 years ) has been disgoned with PSP and is currently taking Syndopa medicine. Please let me know how we can get homeopathic treatment for her as she is based in Mysore , India. Also im hoping there is success in this treatment. Currently her movement is limited due to frequent falls and she has vision issues.

            Thanks,
            Raji

              • Premilife Customer Care says:

                Dear Rajeswari Dhurjati
                Thank you for approaching us.
                We have answered your question in a personal mail sent to you.
                We hope you found our answer sufficient and that it provided you with the information you were looking for.
                If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                The Premilife customer service

                • Premilife Customer Care says:

                  Dear Dhaval
                  Thank you for approaching us.
                  We have answered your question in a personal mail sent to you.
                  We hope you found our answer sufficient and that it provided you with the information you were looking for.
                  If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                  The Premilife customer service

                • Rose says:

                  Hi,

                  I would like to get details on the treatment for the PSP. My mother, 77, was being treated for Parkinson’s, and now the doctor has discovered that it is PSP; She is very weak in terms of movement and balance of the body, with very weakness, can only walk with the help of another person. Speech and deglutition are still reasonable and the memory is still very good. Please inform me about homeopathic treatment.
                  Thanks for the attention,

                  Rose
                  Brazil

                    • Premilife Customer Care says:

                      Dear Rose
                      Thank you for approaching us.
                      We have answered your question in a personal mail sent to you.
                      We hope you found our answer sufficient and that it provided you with the information you were looking for.
                      If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                      The Premilife customer service

                      • Premilife Customer Care says:

                        Dear Rajeev
                        Thank you for approaching us.
                        We have answered your question in a personal mail sent to you.
                        We hope you found our answer sufficient and that it provided you with the information you were looking for.
                        If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
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                      • Moh Vance says:

                        What kind of homeopathic medications do you use for treating PSP?
                        How will these medications help my father?

                          • Premilife Customer Care says:

                            Dear Moh Vance
                            Thank you for approaching us.
                            We have answered your question in a personal mail sent to you.
                            We hope you found our answer sufficient and that it provided you with the information you were looking for.
                            If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                            The Premilife customer service

                          • Rajat Bhatia says:

                            Hiii… My father is 61 years has been disgoned with PSP and is currently taking Levodopa medicine. Please let me know how we can get homeopathic treatment for him as she is based in HISSAR , INDIA

                              • Premilife Customer Care says:

                                Dear Rajat Bhatia
                                Thank you for approaching us.
                                We have answered your question in a personal mail sent to you.
                                We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                The Premilife customer service

                              • Giridhar says:

                                Hi
                                My mother is 69 Years old and in November 2017, she was diagnosed with PSP. Currently she is taking Syndope Plus medication. Could you please advice if there is any treatment in homeopathy.
                                Thanks!
                                Giridhar

                                  • Premilife Customer Care says:

                                    Dear Giridhar
                                    Thank you for approaching us.
                                    We have answered your question in a personal email sent to you.
                                    We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                    If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                    The Premilife customer service

                                    • Premilife Customer Care says:

                                      Dear Barajas
                                      Thank you for approaching us.
                                      We have answered your question in a personal email sent to you.
                                      We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                      If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                      The Premilife customer service

                                      • Premilife Customer Care says:

                                        Dear Toni
                                        Thank you for approaching us.
                                        We have answered your question in a personal email sent to you.
                                        We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                        If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                        The Premilife customer service

                                      • Sarada Pamulapati says:

                                        Hello,
                                        My father 66 years old has been diagnosed with PSP a month ago. He is in a small town in southern part of India.
                                        Please let me know more details about your treatment.
                                        Thanks

                                          • Premilife Customer Care says:

                                            Dear Sarada Pamulapati
                                            Thank you for approaching us.
                                            We have answered your question in a personal email sent to you.
                                            We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                            If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                            The Premilife customer service

                                            • Premilife Customer Care says:

                                              Dear AMIT RAHEJA
                                              Thank you for approaching us.
                                              We have answered your question in a personal email sent to you.
                                              We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                              If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                              The Premilife customer service

                                            • NEERAJ JAGGA says:

                                              Hello,
                                              Please send me information and the treatment available for PSP.
                                              Thank you and appreciate your help.
                                              Neeraj Jagga

                                                • Premilife Customer Care says:

                                                  Dear Neeraj Jagga
                                                  Thank you for approaching us.
                                                  We have answered your question in a personal email sent to you.
                                                  We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                                  If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                                  The Premilife customer service

                                                • Ramiz says:

                                                  Hi,

                                                  My mother (52years ) has been disgoned with PSP and is currently taking Syndopa medicine. Please let me know how we can improve her walking stability and vision. Also im hoping there is success in this treatment. Currently her movement is limited due to frequent falls and she has vision issues.

                                                    • Premilife Customer Care says:

                                                      Dear Ramiz
                                                      Thank you for approaching us.
                                                      We have answered your question in a personal email sent to you.
                                                      We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                                      If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                                      The Premilife customer service

                                                      • Premilife Customer Care says:

                                                        Dear BLAS Reynoso
                                                        Thank you for approaching us.
                                                        We have answered your question in a personal email sent to you.
                                                        We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                                        If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                                        The Premilife customer service

                                                      • Name Sahu says:

                                                        Dear Sir/Mam,

                                                        My mother is 70 Years old and she is suffering from PSP from last 5 years.

                                                        Request you to suggest Homeopathic medicine. We belongs to Kanpur city india.

                                                        Kindly Help. it is very Humble request

                                                          • Premilife Customer Care says:

                                                            Dear Name Sahu
                                                            Thank you for approaching us.
                                                            We have answered your question in a personal email sent to you.
                                                            We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                                            If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                                            The Premilife customer service

                                                          • Sonu says:

                                                            Dear Sir / Madam

                                                            My relative has disease of PSP and taking treatment for this in Vadodara Gujarat (India) but we are not satisfied with the treatment and they are suggested for further treatment at USA

                                                            We want to know about the procedure for treatment and expense

                                                            Patient Name : Sudhaben Vadhela

                                                            Thanks & Regards,
                                                            Sonu

                                                            • Select the disease/s you suffer from: Progressive Supranuclear Palsy
                                                            • Premilife Customer Care says:

                                                              Dear Sonu
                                                              Thank you for approaching us.
                                                              We have answered your question in a personal email sent to you.
                                                              We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                                              If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                                              The Premilife customer service

                                                            • Mangesh Chaurasia says:

                                                              Hi
                                                              I’m from Mumbai (India) .My mother (55 years ) has been disgoned with PSP and is currently taking Syndopa 110 medicine But still she didn’t get relief
                                                              and the problem get increases day by day…please suggest me any experienced doctor how can give her relief for this PSP.

                                                              • Select the disease/s you suffer from: Progressive Supranuclear Palsy
                                                              • Premilife Customer Care says:

                                                                Dear Mangesh Chaurasia
                                                                Thank you for approaching us.
                                                                We have answered your question in a personal email sent to you.
                                                                We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                                                If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                                                The Premilife customer service

                                                              • Shashank says:

                                                                Dear Premilife Team,
                                                                My father aged 69 has been diagnosed with PSP and has severe balance & gait issues along with slurred speech and double vision issue. He is taking Syndopa plus for last 2 yrs. Kindly provide the possible homeopathic treatment for PSP.
                                                                warm regards,

                                                                • Select the disease/s you suffer from: Progressive Supranuclear Palsy
                                                                • Which language do you prefer to get the answer?: English
                                                                • Premilife Customer Care says:

                                                                  Dear Shashank
                                                                  Thank you for approaching us.
                                                                  We have answered your question in a personal email sent to you.
                                                                  We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                                                  If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                                                  The Premilife customer service

                                                                • Shubhangi says:

                                                                  My mother 61 has been diagnosed with PSP, can homeopathic medication be helpful and to what extent? And how can we avail it?

                                                                  • Select the disease/s you suffer from: Progressive Supranuclear Palsy
                                                                  • Which language do you prefer to get the answer?: English
                                                                  • Premilife Customer Care says:

                                                                    Dear Shubhangi
                                                                    Thank you for approaching us.
                                                                    We have answered your question in a personal mail sent to you.
                                                                    We hope you found our answer sufficient and that it provided you with the information you were looking for.
                                                                    If you have further questions, please feel free contacting us using the Contact Premilife page. We will be happy to assist.
                                                                    The Premilife customer service

                                                                  • Nouf says:

                                                                    Hello
                                                                    What kind of homeopathic medications do you use for treating PSP?
                                                                    How will these medications will help my father? and i Need medicine info and know if it will not be conflict with any other medications he takes with knowing that he also has epilepsy so he use Depakote

                                                                    • Select the disease/s you suffer from: Progressive Supranuclear Palsy
                                                                    • Which language do you prefer to get the answer?: English

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