Central Pontine Myelinolysis

Central-Pontine-Myelinolysis

Central pontine myelinolysis (CPM) is a neurological disorder that most frequently occurs after too rapid medical correction of sodium deficiency (hyponatremia).

Central pontine myelinolysis (CPM) is a neurological disorder that most frequently occurs after too rapid medical correction of sodium deficiency (hyponatremia). The rapid rise in sodium concentration is accompanied by the movement of small molecules and pulls water from brain cells. Through a mechanism that is only partly understood, the shift in water and brain molecules leads to the destruction of myelin, a substance that surrounds and protects nerve fibers. Nerve cells (neurons) can also be damaged. Certain areas of the brain are particularly susceptible to myelinolysis, especially the part of the brainstem called the pons. Some individuals will also have damage in other areas of the brain, which is called extrapontine myelinolysis (EPM). Experts estimate that 10 percent of those with CPM will also have areas of EPM.

The initial symptoms of myelinolysis, which begin to appear 2 to 3 days after hyponatremia is corrected, include a depressed level of awareness, difficulty speaking (dysarthria or mutism), and difficulty swallowing (dysphagia). Additional symptoms often arise over the next 1-2 weeks including impaired thinking, weakness or paralysis in the arms and legs, stiffness, impaired sensation, and difficulty with coordination. At its most severe, myelinolysis can lead to coma, “locked-in” syndrome (which is the complete paralysis of all of the voluntary muscles in the body except for those that control the eyes), and death.

Although many affected people improve over weeks to months, some have permanent disability. Some also develop new symptoms later including behavioral or intellectual impairment or movement disorders like parkinsonism or tremor.

Treatment

The ideal treatment for myelinolysis is to prevent the disorder by identifying individuals at risk and following careful guidelines for evaluation and correction of hyponatremia. These guidelines aim to safely restore the serum sodium level, while protecting the brain. For those who have hyponatremia for at least 2 days, or for whom the duration is not known, the rate of rise in the serum sodium concentration should be kept below 10 mmol/L during any 24-hour period, if possible.

For those who develop myelinolysis, treatment is supportive. Some physicians have tried to treat myelinolysis with steroid medication or other experimental therapies, but none has been proven effective. Individuals are likely to require extensive and prolonged physical therapy and rehabilitation. Those patients who develop parkinsonian symptoms may respond to the dopaminergic drugs that work for individuals with Parkinson’s disease. (NIH)

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14 thoughts on “Central Pontine Myelinolysis

  1. Atul Kantak says:

    My mother is suffering with Pontine Myelinolysis due to rapid sodium correction. 98 to 126 within 24 hrs & 126 to 141 in next 24 hrs. She is under semi comatose condition since 5th Nov 2015. Currently she is on allopathic treatment & also we are giving her Ayurveda treatment from Tibetan Relief center Promoted by H H Dalai Laama. Please suggest me any best of the treatment which can be provided to her for her betterment. She just opens her eyes for some time during the day & no other body movement or action. Since last 2 and half month our family is under very bad condition due to her hospitalization & spent huge money beyond our capacity by borrowing from outside.

      • Premilife Customer Care says:

        Dear Atul Kantak
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      • Ameen says:

        Doctor,
        My father (60 yrs, clean habits) had hyponatremia 2 months back( sodium level =93mmol/l) which was corrected in haphazard manner in apollo hospital madurai. It had lead to central pontine myelinosis. Now he is bed ridden ,not speaking, lot of flum and cough, unable to swallow, UTI also .He was admitted in manipal ,bangalore. then we have shifted him to jain hospital ,bangalore.

        His medicines are
        Inj clexane 40 mcg
        T. Levipil-
        T.Syndopa 110mg – 28,
        T. Sicriptin -14
        T. Trivastal 50
        T.cintapro 1 mg
        T. Strolin P 400 –
        T. Mofalert 100 –
        Neb levolin -14
        Neb forocort bd -14
        Moisok eye drop –
        Vitamin D sachet

        Feed is given by peg feed method.Physiotherapy and speech therapy are in progress.
        We need your help on how to get back him to normal position.

          • Premilife Customer Care says:

            Dear Ameen
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            • Premilife Customer Care says:

              Dear Anand
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              • Premilife Customer Care says:

                Dear Rash
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              • Rashnid says:

                Hi,my father is 67 years old,he is suffering osmotic demylination syndrome,now he is in ventilator,please suggest the treatment for him.

                  • Premilife Customer Care says:

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                    • Premilife Customer Care says:

                      Dear K. Siddheshwar
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                      • Premilife Customer Care says:

                        Dear Ishan Sharma
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